Nakla and Phulpur upazilas on the north, Trishal and Fulbaria upazilas on the south, Ishwarganj and Gauripur upazilas on the east, Muktagachha and Jamalpur Sadar upazilas on the west.

Mymensingh Sadar thana, now an upazila, was established in 1867. The upazila consists of 1 municipality, 14 union parishads, 136 mouzas and 173 villages.

Mymensingh Sadar Upazila is located in Mymensingh District. Upazilla(s)/Thana(s) in Mymensingh are Bhaluka Upazila, Dhobaura Upazila, Fulbaria Upazila, Gaffargaon Upazila, Gauripur Upazila, Haluaghat Upazila, Ishwarganj Upazila, Muktagachha Upazila, Mymensingh Sadar Upazila, Nandail Upazila, Phulpur Upazila, Trishal Upazila.

House of Maharaj Shashikanta, Alexandra Castle, Raj Rajeswari Water Tank and "Rabindra Batamul Smritimancha" (in memory of the visit of Mymensingh by Rabindranath Thakur in 1926), most noted items in the Mymensingh Museum are ancient manuscripts of the Mahabharat, Vishnu statue made of black basalt, manuscripts of Gitagovinda of Joydev, manuscripts of the poems of Chandidas, photocopy of the first postal stamp, sword of the zamindar of Muktagachha, World Map (1645), greater Map of the Mymensingh (1779) by Kedarnath Majumder.